Photodruggability

 

 

 

As proposed in: Angew. Chem. Int. Ed. 2016, 55, 10978–10999

As opposed to classical druggability: Nat. Rev. Drug Discovery 2007, 6, 187

The concept of photodruggability includes pharmaceutical druggability, but further restricts it with the following criteria:

1. Responsiveness to Structural Change: Light-induced changes in photo-drug structure should be lead to different bio-activities.

2. Localization: targets should relate to spatially confined diseases (local inflammation, localized infections and tumors)

3. Light-accessibility : How facile is the target reached by light?